炎症与癌症：胰腺中的分子生物学（综述）
Inflammation to cancer: The molecular biology in the pancreas (Review).
作者信息
Ling Sunbin, Feng Tingting, Jia Kaiqi, Tian Yu, Li Yan
机构信息
Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
出版信息
Oncol Lett. 2014 Jun;7(6):1747-1754. doi: 10.3892/ol.2014.2003. Epub 2014 Mar 28.
Abstract
Inflammatory responses are known to be correlated with cancer initiation and progression, and exploration of the route from inflammation to cancer makes a great contribution in elucidating the mechanisms underlying cancer development. Pancreatic cancer (PC) is a lethal disease with a low radical-resection rate and a poor prognosis. As chronic pancreatitis is considered to be a significant etiological factor for PC development, the current review aims to describe the molecular pathways from inflammation to pancreatic carcinogenesis, in support of the strategies for the prevention, diagnosis and treatment of PC.
摘要
已知炎症反应与癌症的发生和发展相关，探索从炎症到癌症的途径对阐明癌症发生的潜在机制有很大贡献。胰腺癌（PC）是一种致命疾病，根治性切除率低且预后不良。由于慢性胰腺炎被认为是胰腺癌发生的一个重要病因，本综述旨在描述从炎症到胰腺癌发生的分子途径，以支持胰腺癌的预防、诊断和治疗策略。
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