Qi Songtao, Yu Lei, Li Hezhen, Ou Yanghui, Qiu Xiaoyu, Ding Yanqing, Han Huixia, Zhang Xuelin
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Oncol Lett. 2014 Jun;7(6):1895-1902. doi: 10.3892/ol.2014.2013. Epub 2014 Mar 28.
The molecular subsets of glioma behave in biologically distinct ways. The present study detected isocitrate dehydrogenase ) 1 and mutations in glioma to analyze whether -mutated gliomas are situated in certain preferential areas and to investigate their correlation with magnetic resonance imaging (MRI) characteristics. A series of 193 patients with astrocytic neoplasms (111 diffuse and 82 anaplastic astrocytomas), grouped according to prelabeled anatomical structures and the risk of surgery, were retrospectively reviewed for 1 and 2 mutations to compare the tumor location and MRI features. A total of 111 1 mutations at codon 132 (57.5%) and six mutations at codon 172 (3.1%) were detected. The mutations were found to predict longer survival, independent of the histological type in this series of patients. The -mutated gliomas were predominantly located in a single lobe, such as the frontal lobe, temporal lobe or cerebellum and rarely in the diencephalon or brain stem. Furthermore, according to the risk of surgery, the -mutated tumors were rarely located in the high-risk regions of the brain, where surgery exhibits a high mortality rate intraoperatively and postoperatively. In addition, gliomas with mutations were significantly more likely to exhibit a unilateral pattern of growth, sharp tumor margins, homogeneous signal intensity and less contrast enhancement on MRI. The results of the current study suggested that the prolonged survival of patients with -mutated gliomas is primarily due to a less aggressive biological behavior according to tumor site and MRI features.
胶质瘤的分子亚群具有生物学上的不同行为。本研究检测了胶质瘤中的异柠檬酸脱氢酶（IDH）1和IDH2突变，以分析IDH突变型胶质瘤是否位于某些特定的优先区域，并研究它们与磁共振成像（MRI）特征的相关性。对一系列193例星形细胞瘤患者（111例弥漫性星形细胞瘤和82例间变性星形细胞瘤）进行回顾性研究，这些患者根据预先标记的解剖结构和手术风险分组，检测IDH1和IDH2突变，以比较肿瘤位置和MRI特征。共检测到111例密码子132处的IDH1突变（57.5%）和6例密码子172处的IDH2突变（3.1%）。在这组患者中，发现IDH突变可预测更长的生存期，与组织学类型无关。IDH突变型胶质瘤主要位于单个脑叶，如额叶、颞叶或小脑，很少位于间脑或脑干。此外，根据手术风险，IDH突变型肿瘤很少位于大脑的高风险区域，这些区域手术的术中及术后死亡率较高。此外，IDH突变的胶质瘤在MRI上更有可能表现为单侧生长模式、肿瘤边界清晰、信号强度均匀且强化程度较低。本研究结果表明，IDH突变型胶质瘤患者生存期延长主要是由于根据肿瘤部位和MRI特征其生物学行为侵袭性较低。
