Department of Neurology, University of California, San Francisco, 94158, USA.
Cancer Cell. 2010 Dec 14;18(6):669-82. doi: 10.1016/j.ccr.2010.10.033.
Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.
恶性神经胶质瘤是最致命的癌症之一。星形细胞瘤中静止和治疗耐药的神经干细胞（NSC）样细胞可能导致预后不良。相比之下，恶性少突胶质细胞瘤对治疗敏感。我们通过磁共振成像（MRI）和详细的发育分析表明，鼠少突胶质细胞瘤细胞表现出少突胶质前体细胞（OPC）的特征，并且对治疗敏感，而 OPC 标志物而非 NSC 标志物富集形成肿瘤。对人类少突胶质细胞瘤的 MRI 也提示了白质（WM）起源，OPC 标志物而非 NSCs 标志物同样富集形成肿瘤。我们的结果表明，少突胶质细胞瘤细胞表现出 OPC 的特征，并且起源于祖细胞而非 NSC，这是该肿瘤患者预后改善的基础。
