Beynel Lysianne, Chauvin Alan, Guyader Nathalie, Harquel Sylvain, Marendaz Christian
Laboratoire de Psychologie et Neurocognition, CNRS UMR 5105, Université Pierre Mendes France, BP 47, 38040 Grenoble Cedex 9, France.
GIPSA-Lab, UMR CNRS 5216, 11 rue des Mathématiques Grenoble Campus, BP46, 38402 Saint Martin d'Heres Cedex Grenoble, France.
Biol Psychol. 2014 Sep;101:9-12. doi: 10.1016/j.biopsycho.2014.05.011. Epub 2014 Jun 13.
This study aimed to assess the impact of aging and 'state-dependency' on cortical excitability. Two studies investigated these factors using a motor task and found that the age-related differences observed at rest disappeared in the task condition. However, as both their tasks and excitability measurements involved the motor cortex, their results could be specific only to the motor system. To overcome this problem, the present study used a cognitive task to control mental state.
Intracortical inhibition/facilitation (ICI/ICF) were assessed in young and older adults at rest and during the cognitive task. The cortical silent period (CSP) was also evaluated.
ICI and CSP were reduced with aging. However, ICI differences between young and old people disappeared when they performed the cognitive task.
Age and mental state modify cortical excitability. Taking these factors into consideration is crucial to clinical research using cortical excitability as a possible biomarker of pathology.
本研究旨在评估衰老和“状态依赖性”对皮质兴奋性的影响。两项研究使用一项运动任务对这些因素进行了调查，结果发现，在静息状态下观察到的与年龄相关的差异在任务状态下消失了。然而，由于他们的任务和兴奋性测量都涉及运动皮层，其结果可能仅适用于运动系统。为克服这一问题，本研究使用一项认知任务来控制心理状态。
在静息状态和认知任务期间，对年轻和年长成年人的皮质内抑制/易化（ICI/ICF）进行评估。还对皮质静息期（CSP）进行了评估。
ICI和CSP随衰老而降低。然而，年轻人和老年人在执行认知任务时，ICI差异消失。
年龄和心理状态会改变皮质兴奋性。在将皮质兴奋性作为可能的病理学生物标志物的临床研究中，考虑这些因素至关重要。
