Ahern Kelly B, Garzon Juan F, Yuruk Deniz, Saliba Maria, Ozger Can, Vande Voort Jennifer L, Croarkin Paul E
Mayo Clinic Alix School of Medicine, 200 First St. SW, Rochester, MN 55905, USA.
Mayo Clinic College of Medicine and Science, 200 First St. SW, Rochester, MN 55905, USA.
Biomedicines. 2023 Jan 30;11(2):409. doi: 10.3390/biomedicines11020409.
The cortical silent period (CSP) and long-interval intracortical inhibition (LICI) are putative markers of γ-aminobutyric acid receptor type B (GABA)-mediated inhibitory neurotransmission. We aimed to assess the association between LICI and CSP in youths.
We analyzed data from three previous studies of youth who underwent CSP and LICI measurements with transcranial magnetic stimulation and electromyography. We assessed CSP and LICI association using Spearman rank correlation tests and multiple linear regression analyses adjusted for demographic and clinical covariates.
The sample included 16 healthy participants and 45 participants with depression. The general mean (SD) age was 15.5 (1.7), 14.3 (1.7) for healthy participants, and 15.9 (1.6) years for participants with depression. Measures were nonnormally distributed (Shapiro-Wilk, < 0.001). CSP and LICI were not correlated at 100-millisecond (ρ = -0.2421, = 0.06), 150-millisecond (ρ = -0.1612, = 0.21), or 200-millisecond (ρ = -0.0507, = 0.70) interstimulus intervals using Spearman rank correlation test. No correlations were found in the multiple regression analysis ( = 0.35).
Although previous studies suggest that cortical silent period and long-interval intracortical inhibition measure GABA receptor-mediated activity, these biomarkers were not associated in our sample of youths. Future studies should focus on the specific physiologic and pharmacodynamic properties assessed by CSP and LICI in younger populations.
皮质静息期（CSP）和长时程皮质内抑制（LICI）被认为是γ-氨基丁酸B型（GABA）介导的抑制性神经传递的标志物。我们旨在评估青少年中LICI与CSP之间的关联。
我们分析了之前三项关于青少年的研究数据，这些青少年接受了经颅磁刺激和肌电图测量CSP和LICI。我们使用Spearman等级相关检验和针对人口统计学和临床协变量进行调整的多元线性回归分析来评估CSP和LICI的关联。
样本包括16名健康参与者和45名抑郁症患者。总体平均（标准差）年龄为15.5（1.7）岁，健康参与者为14.3（1.7）岁，抑郁症患者为15.9（1.6）岁。测量值呈非正态分布（Shapiro-Wilk检验，<0.001）。使用Spearman等级相关检验，在100毫秒（ρ=-0.2421，P=0.06）、150毫秒（ρ=-0.1612，P=0.21）或200毫秒（ρ=-0.0507，P=0.70）的刺激间隔下，CSP和LICI无相关性。在多元回归分析中未发现相关性（P=0.35）。
尽管先前的研究表明皮质静息期和长时程皮质内抑制测量的是GABA受体介导的活动，但在我们的青少年样本中，这些生物标志物并无关联。未来的研究应关注CSP和LICI在较年轻人群中所评估的特定生理和药效学特性。
