Bertrand Fred E, McCubrey James A, Angus C William, Nutter Jennifer M, Sigounas George
Department of Oncology, Brody School of Medicine at East Carolina University, USA.
Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, USA.
Adv Biol Regul. 2014 Sep;56:51-65. doi: 10.1016/j.jbior.2014.05.002. Epub 2014 May 22.
Over the past decade, our understanding of the role that Notch-signaling has in tumorigenesis has shifted from leukemogenesis into cancers of solid tumors. Emerging data suggests that in addition to direct effects mediated through the canonical Notch pathway, Notch may participate in epithelial tumor development through regulation of pathways such as PTEN/PI3K/Akt. Prostate cancer is a disease for which PTEN gene expression is especially essential. This review will summarize a role for Notch in prostate development and cancer with an emphasis on how the Notch pathway may intersect with PTEN/PI3K/Akt and mTOR signaling.
在过去十年中，我们对Notch信号在肿瘤发生中所起作用的理解已从白血病发生转向实体瘤癌症。新出现的数据表明，除了通过经典Notch途径介导的直接作用外，Notch还可能通过调节PTEN/PI3K/Akt等途径参与上皮肿瘤的发展。前列腺癌是一种PTEN基因表达尤为重要的疾病。本综述将总结Notch在前列腺发育和癌症中的作用，重点关注Notch途径如何与PTEN/PI3K/Akt和mTOR信号相互作用。
