Clin Chem Lab Med. 2014 Dec;52(12):1755-61. doi: 10.1515/cclm-2014-0505.
In chronic kidney diseases of various etiologies, the urinary excretion of uromodulin is usually decreased in parallel with the glomerular filtration rate. This study aimed to investigate whether serum uromodulin is associated with kidney function.
Within the framework of the Seniorlabor study, a subset of subjectively healthy individuals 60 years of age and older were included in the study. Serum uromodulin was measured with ELISA. The relationship between serum uromodulin and different stages of kidney function (i.e., cystatin C-based 2012-CKD-EPI eGFRCysC>90 mL/min/1.73 m2, 60-89 mL/min/1.73 m2, 45-59 mL/min/1.73 m2, and <45 mL/min/1.73 m2) was investigated. Furthermore, the relationship between serum uromodulin and other markers of kidney function (i.e., creatinine, cystatin C, and urea) was assessed.
In total, 289 participants (140 males/149 females; mean age 71±7 years) were included in the study. There were significant differences in serum uromodulin among the four groups according to different kidney function stages (p<0.001). Serum uromodulin displayed inverse relationships with creatinine (r=-0.39), cystatin C (r=-0.42), and urea (r=-0.30) and, correspondingly, a positive relationship with eGFRCysC (r=0.38, p<0.001 for all). These associations remained intact when fitting a regression model that incorporated age, gender, body mass index, and current smoking status as covariates.
Serum uromodulin behaves in a manner opposite that of the different conventional renal retention markers by displaying lower concentrations with decreasing kidney function. As uromodulin is produced by the cells of the thick ascending limb of the loop of Henle, lower uromodulin serum levels may reflect a reduction in number or function of these cells in chronic kidney disease.
在各种病因引起的慢性肾脏病中，尿中尿调蛋白的排泄通常与肾小球滤过率平行下降。本研究旨在探讨血清尿调蛋白与肾功能的关系。
在 Seniorlabor 研究中，纳入了年龄在 60 岁及以上的主观健康个体作为研究对象。采用 ELISA 法检测血清尿调蛋白。研究了血清尿调蛋白与不同肾功能阶段（即基于胱抑素 C 的 2012- CKD-EPI eGFRCysC>90 mL/min/1.73 m2、60-89 mL/min/1.73 m2、45-59 mL/min/1.73 m2 和<45 mL/min/1.73 m2）之间的关系。此外，还评估了血清尿调蛋白与其他肾功能标志物（即肌酐、胱抑素 C 和尿素）之间的关系。
本研究共纳入 289 名参与者（140 名男性/149 名女性；平均年龄 71±7 岁）。根据不同的肾功能阶段，四组间血清尿调蛋白有显著差异（p<0.001）。血清尿调蛋白与肌酐（r=-0.39）、胱抑素 C（r=-0.42）和尿素（r=-0.30）呈负相关，与 eGFRCysC 呈正相关（r=0.38，p<0.001）。当拟合一个回归模型，纳入年龄、性别、体重指数和当前吸烟状况作为协变量时，这些相关性仍然存在。
血清尿调蛋白的行为与不同的传统肾潴留标志物相反，随着肾功能的下降，其浓度降低。由于尿调蛋白是由 Henle 袢升支粗段的细胞产生的，因此血清中尿调蛋白水平降低可能反映了这些细胞在慢性肾脏病中的数量或功能减少。
