Thauvin C, Lecomte F, Le Boete I, Grise G, Lemeland J F
Laboratoire de Bactériologie et Unité, INSERM 295, Hôtel Dieu, Rouen.
Infection. 1989 Jan-Feb;17(1):31-4. doi: 10.1007/BF01643497.
The efficacy of ciprofloxacin alone and in combination with azlocillin was compared with that of azlocillin plus tobramycin in a rat model of aortic valve endocarditis due to Pseudomonas aeruginosa. MICs against the infecting strain of ciprofloxacin, azlocillin and tobramycin were 0.125, 8, and 0.5 mg/l, respectively. Antimicrobials were administered 24 h after bacterial challenge and for six days. Mean peak/trough serum levels for ciprofloxacin (50 mg/kg i.v. q 12 h), azlocillin (500 mg/kg i.v. q 12 h) and tobramycin (6.5 mg/kg i.v. q 12 h) were: 10.5/0.2, 386/less than 16, and 6.2/less than 0.6 mg/l, respectively. Ciprofloxacin alone was more effective than the combination azlocillin-tobramycin in increasing survival (p less than 0.05), sterilizing blood (p less than 0.05) and valves (p less than 0.001), and in reducing bacterial titers in vegetations (p less than 0.001). Ciprofloxacin-azlocillin combination was not more effective than ciprofloxacin alone. Drug resistance was not encountered in post-treatment isolates with any therapy regimen.
在铜绿假单胞菌所致主动脉瓣心内膜炎的大鼠模型中，比较了环丙沙星单独使用及其与阿洛西林联合使用的疗效，并与阿洛西林加妥布霉素的疗效进行了对比。环丙沙星、阿洛西林和妥布霉素对感染菌株的最低抑菌浓度分别为0.125、8和0.5mg/l。在细菌攻击后24小时给予抗菌药物，并持续6天。环丙沙星（50mg/kg静脉注射，每12小时一次）、阿洛西林（500mg/kg静脉注射，每12小时一次）和妥布霉素（6.5mg/kg静脉注射，每12小时一次）的平均峰/谷血清水平分别为：10.5/0.2、386/低于16和6.2/低于0.6mg/l。单独使用环丙沙星在提高生存率（p<0.05）、清除血液（p<0.05）和瓣膜（p<0.001）以及降低赘生物中的细菌滴度（p<0.001）方面比阿洛西林-妥布霉素联合用药更有效。环丙沙星-阿洛西林联合用药并不比单独使用环丙沙星更有效。任何治疗方案的治疗后分离株均未出现耐药性。
