环丙沙星对需氧革兰氏阴性菌的体外活性。
In vitro activity of ciprofloxacin against aerobic gram-negative bacteria.
作者信息
Rudin J E, Norden C W, Shinners E M
出版信息
Antimicrob Agents Chemother. 1984 Oct;26(4):597-8. doi: 10.1128/AAC.26.4.597.
Abstract
For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrowth by 24 h, with development of partial resistance to ciprofloxacin.
摘要
对于177株革兰氏阴性菌分离株，环丙沙星的最低抑菌浓度（MIC）范围为0.02微克/毫升（大肠杆菌）至0.31微克/毫升（铜绿假单胞菌）。在时间-杀菌曲线中，8倍MIC的环丙沙星在24小时内几乎完全杀灭了10⁶CFU的铜绿假单胞菌。4倍MIC的环丙沙星在24小时时允许细菌重新生长，并出现对环丙沙星的部分耐药性。
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