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本文引用的文献

1
In vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substituted quinoline derivatives.环丙沙星与其他新型含氟哌嗪基取代喹啉衍生物的体外活性比较。
Antimicrob Agents Chemother. 1984 Apr;25(4):518-21. doi: 10.1128/AAC.25.4.518.
2
In vitro activity of ciprofloxacin, a new carboxyquinoline antimicrobial agent.新型羧基喹啉抗菌剂环丙沙星的体外活性
Antimicrob Agents Chemother. 1984 Mar;25(3):331-5. doi: 10.1128/AAC.25.3.331.
3
Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria.环丙沙星，一种对需氧菌和厌氧菌均有活性的喹诺酮羧酸化合物。
Antimicrob Agents Chemother. 1984 Mar;25(3):319-26. doi: 10.1128/AAC.25.3.319.
4
In vitro activity of ciprofloxacin (Bay o 9867).环丙沙星（拜耳o 9867）的体外活性。
Antimicrob Agents Chemother. 1983 Oct;24(4):568-74. doi: 10.1128/AAC.24.4.568.
5
Comparative activities of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and nalidixic acid.环丙沙星（拜奥9867）、诺氟沙星、吡哌酸和萘啶酸的比较活性。
Antimicrob Agents Chemother. 1983 Aug;24(2):302-4. doi: 10.1128/AAC.24.2.302.
6
In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.新型喹啉衍生物Bay 09867与其他抗菌药物的体外活性比较。
Antimicrob Agents Chemother. 1983 Apr;23(4):559-64. doi: 10.1128/AAC.23.4.559.
7
A method for testing for synergy with any number of agents.一种用于测试与任意数量药剂协同作用的方法。
J Infect Dis. 1978 Feb;137(2):122-30. doi: 10.1093/infdis/137.2.122.

环丙沙星对需氧革兰氏阴性菌的体外活性。

In vitro activity of ciprofloxacin against aerobic gram-negative bacteria.

作者信息

Rudin J E, Norden C W, Shinners E M

出版信息

Antimicrob Agents Chemother. 1984 Oct;26(4):597-8. doi: 10.1128/AAC.26.4.597.

DOI:10.1128/AAC.26.4.597
PMID:6517550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC179973/
Abstract

For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrowth by 24 h, with development of partial resistance to ciprofloxacin.

摘要

对于177株革兰氏阴性菌分离株，环丙沙星的最低抑菌浓度（MIC）范围为0.02微克/毫升（大肠杆菌）至0.31微克/毫升（铜绿假单胞菌）。在时间-杀菌曲线中，8倍MIC的环丙沙星在24小时内几乎完全杀灭了10⁶CFU的铜绿假单胞菌。4倍MIC的环丙沙星在24小时时允许细菌重新生长，并出现对环丙沙星的部分耐药性。