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腔内型膀胱肿瘤的诊断与治疗。

Diagnosis and management of intradiverticular bladder tumours.

机构信息

Department of Urology, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

出版信息

Nat Rev Urol. 2014 Jul;11(7):383-90. doi: 10.1038/nrurol.2014.131. Epub 2014 Jun 17.

Abstract

Intradiverticular bladder tumours (IDBT) account for approximately 1% of all urinary bladder tumours. The risk of developing a tumour within a bladder diverticulum is considered to be greater than in the main bladder, possibly owing to prolonged contact of potential carcinogens with the mucosal lining from urinary stasis. Patients with these tumours most commonly present with visible haematuria. Diagnostic tests include urine cytology, cystoscopy, ultrasonography, CT, MRI, and biopsy. Lack of muscle in the diverticula increases the risk of bladder perforation during biopsy and makes pathological staging difficult as there is no T2 stage; instead, data suggest that any invasion beyond the lamina propria should be described as T3. IDBT can be managed by transurethral resection and adjuvant intravesical therapy, diverticulectomy, or cystectomy (partial or radical), as outlined by the only guidelines to specifically address the management of IDBT, which were published by the Cancer Committee of the French Association of Urology (CCAFU) in 2012. The prognosis of patients with intradiverticular bladder tumours has always been perceived to be worse than those with intravesical tumours; however, the only study of 5-year survival rates for patients with IDBT suggests that prognosis might be comparable for these conditions.

摘要

腔内膀胱肿瘤(IDBT)约占所有膀胱肿瘤的 1%。在膀胱憩室内形成肿瘤的风险被认为高于在主膀胱中,这可能是由于潜在致癌物质因尿液停滞而与黏膜衬里长时间接触所致。这些肿瘤的患者最常出现可见血尿。诊断测试包括尿液细胞学检查、膀胱镜检查、超声检查、CT、MRI 和活检。憩室内缺乏肌肉会增加活检时膀胱穿孔的风险,并使病理分期变得困难,因为没有 T2 期;相反,有数据表明,任何超出固有层的侵犯都应描述为 T3。腔内膀胱肿瘤可通过经尿道切除术和辅助膀胱内治疗、憩室切除术或膀胱部分切除术(部分或根治性)来治疗,这是由法国泌尿外科协会癌症委员会(CCAFU)于 2012 年发布的专门针对腔内膀胱肿瘤管理的唯一指南中规定的。腔内膀胱肿瘤患者的预后一直被认为比腔内肿瘤患者差;然而,唯一一项关于 IDBT 患者 5 年生存率的研究表明,这些情况下的预后可能相当。

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