1] Advanced Membranes and Porous Materials Center, 4700 King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia [2].
Water Desalination and Reuse Center, 4700 King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.
Nat Commun. 2014 Jun 17;5:4110. doi: 10.1038/ncomms5110.
The design of micro- or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances.
用于生物技术和医学应用中封装敏感分子（如药物、激素、蛋白质或肽）的微纳米粒子的设计变得日益重要。此类敏感分子的封装载体包括胶束、脂质体和囊泡。这些微小的（在大多数情况下为中空）球体通常被用作药物或营养物质的输送和控制给药的载体。在这里，我们报告了一种通过嵌段共聚物自组装来制备微球的简单策略。这些微球颗粒具有单分散的纳米孔，可充当 pH 响应性门。它们具有高度多孔的内部结构，类似于 Schwarz P 结构。颗粒的内部孔隙率有助于其具有高吸附能力和持续释放行为。我们成功地使用这些颗粒分离了类似大小的蛋白质。通过相分离和自组装来制备颗粒的简易性，以及颗粒的坚固性使它们成为用于吸附、分离、输送和持续递药的理想选择。
