来自绿桤木树皮的二芳基庚烷类化合物及其DNA保护潜力。
Diarylheptanoids from green alder bark and their potential for DNA protection.
作者信息
Novaković Miroslav, Stanković Miroslava, Vučković Ivan, Todorović Nina, Trifunović Snežana, Apostolović Danijela, Mandić Boris, Veljić Milan, Marin Petar, Tešević Vele, Vajs Vlatka, Milosavljević Slobodan
机构信息
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 16, RS-11000 Belgrade (phone: +381-11-2630474; fax: +381-11-2636061).
出版信息
Chem Biodivers. 2014 Jun;11(6):872-85. doi: 10.1002/cbdv.201300277.
Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
从绿桤木（Alnus viridis）树皮中分离出9种二芳基庚烷类化合物（1 - 9）、儿茶素（11）和一种酚苷（10）。分离得到的化合物中有4种，即2、5、8、10，是新化合物。根据光谱数据确定了1 - 11的结构。使用胞质分裂阻滞微核（CBMN）试验，对所有分离得到的化合物在体外对人外周血淋巴细胞染色体畸变的保护作用进行了评估。几乎所有化合物都对降低人淋巴细胞的DNA损伤有显著作用，其作用比已知的合成保护剂氨磷汀更强。
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