Tung Nguyen Huu, Ra Jeong Chan, Sohn Dong Hwan, Kim Young Ho
College of Pharmacy, Chungnam National University, Daejeon, South Korea.
J Asian Nat Prod Res. 2010 Oct;12(10):921-4. doi: 10.1080/10286020.2010.507196.
A new diarylheptanoid, epihirsutanonol (1), was isolated from the bark of Alnus japonica, along with two known ones (2 and 3). Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay.
从日本桤木树皮中分离出一种新的二芳基庚烷类化合物表hirsutanonol（1），以及两种已知化合物（2和3）。基于广泛的光谱证据阐明了它们的结构。在体外实验中，新化合物1对叔丁基过氧化氢诱导的肝细胞损伤表现出显著的肝保护活性。
