Lannang Alain Meli, Tatsimo Simplice J N, Fouotsa Hugues, Dzoyem Jean Paul, Saxena Ajit Kumar, Sewald Norbert
Department of Organic Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon, (phone: +237-77-534830; fax: +237-22-229116); Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld.
Chem Biodivers. 2014 Jun;11(6):975-81. doi: 10.1002/cbdv.201300401.
A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
从多花山竹子的叶子中分离出一种名为班甘氧杂蒽酮C（=12-(1,1-二甲基丙-2-烯-1-基)-5,10-二羟基-9-甲氧基-2-甲基-2-(4-甲基戊-3-烯-1-基)-2H,6H-吡喃并[3,2-b]氧杂蒽-6-酮；4）的新化合物以及五种已知化合物。基于一维和二维核磁共振光谱对这些化合物的结构进行了阐明。在这些已知化合物中，两种是氧杂蒽酮，一种是五环三萜，一种是甾醇，还有一种是二苯甲酮衍生物。异氧杂色原酮（2）和4-[(2E)-3,7-二甲基辛-2,6-二烯-1-基]-1,5,8-三羟基-3-甲氧基-9H-氧杂蒽-9-酮（3）对白血病细胞系TPH-1表现出显著的抗增殖活性，IC50抑制值分别为1.5和2.8 μg/ml。发现细胞毒性活性与诱导凋亡有关。
