Li Da-Hong, Li Chen-Xi, Jia Cui-Cui, Sun Ya-Ting, Xue Chun-Mei, Bai Jiao, Hua Hui-Ming, Liu Xiao-Qiu, Li Zhan-Lin
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Processes, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, 222001, People's Republic of China.
Arch Pharm Res. 2016 Feb;39(2):172-177. doi: 10.1007/s12272-015-0692-6. Epub 2015 Dec 10.
Three new xanthones, paucinervins H-J (1-3), as well as eleven known compounds (4-14), were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds (1-3) were elucidated by 1D, 2D NMR spectra and HR ESIMS. In vitro antiproliferative activity against human promyelocytic leukemia HL-60 cells was tested, among which, compounds 2, 5, 6 and 7 exhibited strong growth inhibitory effects with GI50 values ranging from 1.30 to 9.08 μM, respectively. Preliminary SARs were also discussed.
从少脉藤黄的叶子中分离出三种新的呫吨酮类化合物，即少脉藤黄素H-J（1-3），以及十一种已知化合物（4-14）。通过一维、二维核磁共振光谱和高分辨电喷雾电离质谱对新化合物（1-3）的结构进行了鉴定。测试了它们对人早幼粒细胞白血病HL-60细胞的体外抗增殖活性，其中化合物2、5、6和7表现出较强的生长抑制作用，其半数生长抑制浓度（GI50）值分别为1.30至9.08 μM。还讨论了初步的构效关系。
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