Dalbeni Andrea, Delva Pietro, Minuz Pietro
Section of Internal Medicine, Department of Biomedical and Surgical Science, University of Verona, Policlinico "GB Rossi", P.le Scuro 1, 37134, Verona, Italy,
Am J Cardiovasc Drugs. 2014 Oct;14(5):357-66. doi: 10.1007/s40256-014-0080-5.
Vitamin D deficiency may play a role in the pathogenesis of chronic heart failure (HF), but whether giving patients supplements to raise vitamin D into the normal range improves their survival is not clear. It has been demonstrated that vitamin D deficiency is common in patients with HF, especially the elderly, in obese and in dark skinned people, and that low vitamin D levels are associated with adverse outcome. The epidemiological data have been confirmed by experimental data, which show that knockout mice for the vitamin D receptor developed myocardial hypertrophy and dysfunction. Data from interventional studies are scarce and discordant, and more research is urgently needed to confirm whether add-on supplementation therapy with vitamin D has a role in the management of patients with chronic HF.
维生素D缺乏可能在慢性心力衰竭（HF）的发病机制中起作用，但给予患者补充剂使维生素D水平升至正常范围是否能改善其生存率尚不清楚。已有研究表明，HF患者中维生素D缺乏很常见，尤其是老年人、肥胖者和肤色较深的人，且低维生素D水平与不良预后相关。流行病学数据已得到实验数据的证实，实验数据显示维生素D受体基因敲除小鼠会出现心肌肥大和功能障碍。干预性研究的数据稀少且不一致，因此迫切需要更多研究来证实维生素D补充疗法在慢性HF患者管理中是否有作用。
