Radiopharmacy, Institute of Energy and Nuclear Research, Sao Paulo
Radiopharmacy, Institute of Energy and Nuclear Research, Sao Paulo.
Med Mycol. 2014 Jul;52(5):546-51. doi: 10.1093/mmy/myu024. Epub 2014 Jun 15.
Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. The peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. The radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, with marked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM.
球孢子菌病（PCM）是一种由热双相真菌巴西副球孢子菌引起的慢性肉芽肿性疾病。它在拉丁美洲的一些国家流行，可引起高负担的真菌感染，具有较高的发病率和死亡率。肽 P10 对实验性 PCM 具有免疫保护作用，已用放射性同位素进行放射性标记，并在体内进行了评估。放射性标记是为了追踪该分子在主要器官和组织中的药代动力学。这是通过高放射化学纯度来实现的。生物分布和闪烁成像显示，血液清除速度很快，主要通过肾脏；但也有肝胆排泄，颈部淋巴结摄取明显。这种特征可能有助于为接触 PCM 的患者开发预防性药物或疫苗。
