Bonnefont-Rousselot Dominique
Service de Biochimie Metabolique, Groupe hospitalier Pitie-Salpetriere (Assistance Publique - Hopitaux de Paris), 47-83 boulevard de l'Hopital, 75651 Paris Cedex 13, France.
Endocr Metab Immune Disord Drug Targets. 2014;14(3):159-68. doi: 10.2174/1871530314666140604151452.
Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e.g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity.
肥胖与氧化应激状态相关，氧化应激状态的定义是与天然防御系统中抗氧化剂的作用水平相比，活性氧（ROS）产生过多。在肥胖中可以确定几种ROS来源（例如，线粒体呼吸链或NADPH氧化酶），它们可能导致肥胖的发病机制。实际上，这些情况通过脂肪因子和促炎细胞因子的失调促进胰岛素抵抗和代谢综合征的发展，因此将抗氧化治疗策略与减肥策略相结合可能会很有意义。在抗氧化剂中，褪黑素占有特殊地位，一方面是因为其抗氧化和抗炎特性，另一方面是因为其作为代谢调节剂的作用。由于褪黑素调节肥胖及其相关代谢改变中涉及的几个过程，它可能对肥胖治疗具有治疗意义。
