Cohen N, Modai D, Golik A, Eshkoly M, Theitler J, Scapa E
Department of Medicine, Sackler School of Medicine, Tel-Aviv University, Zerifin, Israel.
J Clin Gastroenterol. 1989 Feb;11(1):68-9. doi: 10.1097/00004836-198902000-00017.
A 70-year-old woman free of renal or hepatic dysfunction developed reversible mental confusion, sinus bradycardia, and extreme QT interval prolongation following initiation of intravenous cimetidine 1200 mg daily. The association of mental confusion with cardiac conduction impairment in a single patient in the context of cimetidine toxicity is highly unusual. We review this and other reports on potentially fatal cimetidine-related cardiac conduction disturbances to suggest that in patients at risk, in addition to reducing cimetidine dosage, electrocardiogram (ECG) follow-up is indicated to identify dangerous bradycardia and QT interval prolongation.
一名70岁、无肾或肝功能障碍的女性在开始每日静脉注射1200毫克西咪替丁后出现了可逆性精神错乱、窦性心动过缓和QT间期极度延长。在西咪替丁毒性背景下，单一患者出现精神错乱与心脏传导障碍相关的情况非常罕见。我们回顾了这一病例以及其他关于西咪替丁相关潜在致命性心脏传导紊乱的报告，以表明对于有风险的患者，除了减少西咪替丁剂量外，还应进行心电图（ECG）随访，以识别危险的心动过缓和QT间期延长。
