Prinsloo Sarah, Wei Qi, Scott Shellie M, Tannir Nizar, Jonasch Eric, Pisters Louis, Cohen Lorenzo
Unit 410, Department of General Oncology and the Integrative Medicine Program, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230, USA,
J Behav Med. 2015 Feb;38(1):48-56. doi: 10.1007/s10865-014-9578-1. Epub 2014 Jun 17.
This study sought to determine if there was an association between prognostic-based serum biomarkers, survival, and psychosocial factors in patients with metastatic renal cell carcinoma. Associations were found between psychosocial factors and biomarker levels (hemoglobin with depressive symptoms (r = -0.29), positive affect (r = 0.30), social support (r = 0.19), and perceived stress (r = -0.27); albumin with depressive symptoms (r = -0.19), positive affect (r = 0.22), and social support (r = 0.20); alkaline phosphatase with depressive symptoms (r = 0.21), all p values <0.05. After adjustment for disease-related risk factors, only the associations between positive affect and perceived stress with hemoglobin remained significant (p's < 0.05). Positive affect (HR = 0.90; 95% CI = 0.83, 0.97; p = 0.009) and depressive symptom total scores (HR = 1.03; 95% CI = 1.01, 1.06; p = 0.013), and alkaline phosphatase (HR 2.72; 95% CI = 1.41, 5.24; p = 0.003) were associated with survival. This study suggests that measures of positive and negative psychological outlook may contribute differently to health, well-being, and survival.
本研究旨在确定转移性肾细胞癌患者基于预后的血清生物标志物、生存率和心理社会因素之间是否存在关联。研究发现心理社会因素与生物标志物水平之间存在关联（血红蛋白与抑郁症状（r = -0.29）、积极情绪（r = 0.30）、社会支持（r = 0.19）和感知压力（r = -0.27）；白蛋白与抑郁症状（r = -0.19）、积极情绪（r = 0.22）和社会支持（r = 0.20）；碱性磷酸酶与抑郁症状（r = 0.21），所有p值<0.05。在对疾病相关危险因素进行调整后，只有积极情绪和感知压力与血红蛋白之间的关联仍然显著（p值<0.05）。积极情绪（HR = 0.90；95%CI = 0.83，0.97；p = 0.009）、抑郁症状总分（HR = 1.03；95%CI = 1.01，1.06；p = 0.013）和碱性磷酸酶（HR 2.72；95%CI = 1.41，5.24；p = 0.003）与生存率相关。本研究表明，积极和消极心理状态的衡量指标可能对健康、幸福感和生存率有不同的影响。
