Amonoo Hermioni L, Daskalakis Elizabeth, Lam Jeffrey A, Wolfe Emma D, Guo Michelle, Onyeaka Henry K, Newcomb Richard A, Barata Anna, Ghanime Pia Maria, Keane Emma P, Boardman Annabella C, Cutler Corey, Pirl William F, Peteet John R, Gudenkauf Lisa M, Lee Stephanie J, Huffman Jeff C, El-Jawahri Areej
Department of Psychosocial Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
J Psychosoc Oncol. 2025;43(3):373-388. doi: 10.1080/07347332.2024.2410929. Epub 2024 Oct 7.
To examine the associations between state positive psychological well-being (PPWB) constructs, mood, and quality of life (QOL) in hematopoietic stem cell transplantation (HSCT) survivors.
The study was a secondary analysis of cross-sectional data.
SAMPLE/METHODS: We analyzed self-report data assessing positive affect, flourishing, QOL, depression and anxiety, and PTSD symptoms from 158 allogeneic HSCT recipients at day-100 post-transplant enrolled in supportive care studies.
Univariate analysis showed that factors associated with greater levels of various state PPWB constructs include older age, disability status, greater social support, and presence of graft-versus-host disease. Multivariate analysis showed that state PPWB constructs-greater levels of positive affect and flourishing-were significantly associated with better QOL and lower PTSD, anxiety, and depression symptomatology.
Our findings suggest that longitudinal studies are needed to examine the links between state PPWB constructs and HSCT outcomes, which may inform population specific interventions and opportunities to improve outcomes.
探讨造血干细胞移植（HSCT）幸存者的状态积极心理健康（PPWB）构念、情绪和生活质量（QOL）之间的关联。
该研究是对横断面数据的二次分析。
样本/方法：我们分析了158名异基因HSCT受者在移植后100天的自我报告数据，这些数据评估了积极情绪、蓬勃发展、生活质量、抑郁和焦虑以及创伤后应激障碍（PTSD）症状，他们均参与了支持性护理研究。
单因素分析表明，与各种状态PPWB构念水平较高相关的因素包括年龄较大、残疾状况、更大的社会支持以及移植物抗宿主病的存在。多因素分析表明，状态PPWB构念——更高水平的积极情绪和蓬勃发展——与更好的生活质量以及更低的PTSD、焦虑和抑郁症状显著相关。
我们的研究结果表明，需要进行纵向研究来检验状态PPWB构念与HSCT结果之间的联系，这可能为针对特定人群的干预措施和改善结果的机会提供信息。
