Zhao Jinbing, Chen Zhi, Xi Guohua, Keep Richard F, Hua Ya
Department of Neurosurgery, University of Michigan, R5018 Biomedical Science Research Building, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Transl Stroke Res. 2014 Oct;5(5):586-94. doi: 10.1007/s12975-014-0353-y. Epub 2014 Jun 17.
Acute post-traumatic ventricular dilation and hydrocephalus are relatively frequent consequences of traumatic brain injury (TBI). Several recent studies have indicated that high iron levels in brain may relate to hydrocephalus development after intracranial hemorrhage. However, the role of iron in the development of post-traumatic hydrocephalus is still unclear. This study was to determine whether or not iron has a role in hydrocephalus development after TBI. TBI was induced by lateral fluid-percussion in male Sprague-Dawley rats. Some rats had intraventricular injection of iron. Acute hydrocephalus was measured by magnetic resonance T2-weighted imaging and brain hemorrhage was determined by T2* gradient-echo sequence imaging and brain hemoglobin levels. The effect of deferoxamine on TBI-induced hydrocephalus was examined. TBI resulted in acute hydrocephalus at 24 h (lateral ventricle volume: 24.1 ± 3.0 vs. 9.9 ± 0.2 mm(3) in sham group). Intraventricular injection of iron also caused hydrocephalus (25.7 ± 3.4 vs. 9.0 ± 0.6 mm(3) in saline group). Deferoxamine treatment attenuated TBI-induced hydrocephalus and heme oxygenase-1 upregulation. In conclusion, iron may contribute to acute hydrocephalus after TBI.
急性创伤后脑室扩张和脑积水是创伤性脑损伤（TBI）相对常见的后果。最近的几项研究表明，脑内高铁水平可能与颅内出血后脑积水的发生有关。然而，铁在创伤后脑积水发生中的作用仍不清楚。本研究旨在确定铁在TBI后脑积水发生中是否起作用。通过对雄性Sprague-Dawley大鼠进行侧方液压冲击诱导TBI。部分大鼠进行脑室内铁注射。通过磁共振T2加权成像测量急性脑积水，并通过T2*梯度回波序列成像和脑血红蛋白水平确定脑出血情况。研究了去铁胺对TBI诱导的脑积水的影响。TBI导致24小时出现急性脑积水（侧脑室体积：24.1±3.0 vs.假手术组的9.9±0.2mm³）。脑室内注射铁也导致脑积水（25.7±3.4 vs.生理盐水组的9.0±0.6mm³）。去铁胺治疗减轻了TBI诱导的脑积水和血红素加氧酶-1上调。总之，铁可能促成TBI后的急性脑积水。
