Butt Mark Timothy, Whitney Katharine Mason, Davis Wendell, Akella Surekha, Parker Suezanne, Foley George L
Tox Path Specialists, LLC, Frederick, Maryland, USA.
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA
Toxicol Pathol. 2015 Jun;43(4):513-8. doi: 10.1177/0192623314537723. Epub 2014 Jun 16.
Brain sections from control cynomolgus monkeys (Macaca fascicularis) used in toxicology studies were evaluated retrospectively in order to better understand spontaneous background changes in this species. Hematoxylin and eosin-stained slides from 76 animals (38 males and 38 females) of 9 studies were examined. Eleven animals (9 males and 2 females) were each observed to have 1 to 3 findings within the brain sections examined, for a total of 19 findings. No findings were noted in the spinal cord. The most common finding was focal to multifocal perivascular infiltration of mononuclear cells, affecting the parenchyma, the meninges, or the choroid plexus. Additionally, focal gliosis was observed in 6 animals and a single focus of hemosiderin deposition (coincident with focal gliosis and mononuclear cell infiltrate) was noted in 1 animal. Most of the glial foci were composed of cells consistent with microglial cells, with or without admixed lymphocytes. All findings were of slight or minimal severity, lacked an apparent cause, and were considered incidental and of negligible biologic significance. An awareness of the spontaneous incidence of these background findings may facilitate the discernment of toxicologically relevant effects when these findings are observed.
为了更好地了解食蟹猴（猕猴）的自发性背景变化，对毒理学研究中使用的对照食蟹猴的脑切片进行了回顾性评估。检查了来自9项研究的76只动物（38只雄性和38只雌性）的苏木精和伊红染色切片。在检查的脑切片中，分别观察到11只动物（9只雄性和2只雌性）有1至3个病变，共计19个病变。脊髓中未发现病变。最常见的病变是单核细胞的局灶性至多灶性血管周围浸润，累及实质、脑膜或脉络丛。此外，在6只动物中观察到局灶性胶质细胞增生，在1只动物中发现单个含铁血黄素沉积灶（与局灶性胶质细胞增生和单核细胞浸润一致）。大多数胶质病灶由与小胶质细胞一致的细胞组成，有或没有混合淋巴细胞。所有病变的严重程度均为轻度或极轻度，缺乏明显病因，被认为是偶然的，生物学意义可忽略不计。当观察到这些病变时，了解这些背景病变的自发发生率可能有助于辨别毒理学相关效应。
