Tsuchiya M, Shinozaki J, Hashida I, Kawaguchi T, Yamashita T, Kaneta K
Dept. of Radiotherapy, Cancer Institute Hospital.
Gan No Rinsho. 1989 Jan;35(1):9-14.
From 1980 to 1985, 126 patients with a brain metastases from various malignant tumors were treated by hypervoltage irradiation with conventional fractionation at the Department of Radiotherapy at the Cancer Institute Hospital. The patients without an extracranial metastases or without neurological symptoms had a longer survival than did the other patients. Radiotherapy of more than 30 Gy improved the neurological functions and reduced the risk of death from the brain metastases. For long-term local control of brain metastases, whole brain irradiation with boost therapy for localized lesions may be a better treatment than other radiation methods and the total radiation dose required may be more than 50 Gy.
1980年至1985年期间,癌症研究所医院放疗科采用常规分割的超高压照射法,对126例患有各种恶性肿瘤脑转移的患者进行了治疗。没有颅外转移或没有神经症状的患者比其他患者存活时间更长。超过30 Gy的放射治疗改善了神经功能,并降低了脑转移导致的死亡风险。为了对脑转移进行长期局部控制,对局部病变采用全脑照射加强化治疗可能比其他放射治疗方法更好,所需的总放射剂量可能超过50 Gy。