碳酸锂治疗酒精中毒的对照研究。

A controlled study of lithium carbonate in the treatment of alcoholism.

作者信息

de la Fuente J R, Morse R M, Niven R G, Ilstrup D M

机构信息

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905.

出版信息

Mayo Clin Proc. 1989 Feb;64(2):177-80. doi: 10.1016/s0025-6196(12)65672-9.

DOI:10.1016/s0025-6196(12)65672-9

PMID:2493536

Abstract

A prospective double-blind placebo-controlled trial conducted during a 6-month period showed that lithium carbonate was no better than placebo in producing total abstinence in patients with alcoholism, regardless of whether they were depressed. A high dropout rate, the effect of compliance, and difficulties in measuring improvement in these patients impose some limitations in interpreting the results of this study.

摘要

一项为期6个月的前瞻性双盲安慰剂对照试验表明，无论酗酒患者是否伴有抑郁，碳酸锂在促使他们完全戒酒方面并不比安慰剂效果更好。高失访率、依从性的影响以及衡量这些患者病情改善情况的困难给解读这项研究的结果带来了一些限制。