[卡介苗多灶性骨髓炎。病例报告]

[BCG multifocal osteomyelitis. A case report].

作者信息

Ben Ghozlen H, Jerbi M, Zitoun Y, Abid F, Bousoffara R, Sassi N

机构信息

Service d'orthopédie, hôpital Tahar Sfar, Mahdia, Tunisie.

出版信息

Arch Pediatr. 2014 Jul;21(7):761-4. doi: 10.1016/j.arcped.2014.04.020. Epub 2014 Jun 13.

DOI:10.1016/j.arcped.2014.04.020

PMID:24935450

Abstract

Multifocal osteomyelitis is a rare complication of the Bacille Calmette-Guerin (BCG) vaccine. It particularly affects immunocompromised children and poses a difficult diagnostic problem. A 6-month-old boy had BCG vaccination postnatally and developed extensive disseminated skeletal osteomyelitis. He was found to have severe combined immunodeficiency. Despite antibiotic therapy and bone marrow grafting, the disease was fatal.

摘要

多灶性骨髓炎是卡介苗（BCG）疫苗接种的一种罕见并发症。它尤其影响免疫功能低下的儿童，并且带来了诊断难题。一名6个月大的男婴出生后接种了卡介苗，并发展为广泛播散性骨骼骨髓炎。他被发现患有严重联合免疫缺陷。尽管进行了抗生素治疗和骨髓移植，该疾病仍为致命性的。