He Wen-Ting, Liu Tao, Tang Xiao-Fan, Li Yu-Min
Second Hospital of Lanzhou University, Lanzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(9):4067-70. doi: 10.7314/apjcp.2014.15.9.4067.
The Chinese Hui ethnic group has diverse origins, including Arab, Persian, Central Asian, and Mongol. The standardized mortality rate of gastric cancer in the Hui population is higher than the overall Chinese population. In this study, we investigated whether COX-2-765G>C polymorphism, an extensively studied polymorphism, contributes to gastric cancer and its precursor lesions (GPL) in the Chinese Hui ethnic group.
COX-2-765G>C polymorphism was determined by pyrosequencing in 100 gastric cancer cases, 102 gastric cancerand its precursor lesions cases and 105 controls. Data were statistically analyzed using Chi-square tests and logistic regression models.
Among the Chinese Hui ethnic group COX-2 -765 C allele carriers were at increased risk for gastric cancer (OR=1.977, 95%CI=1.104-3.541). We also found an interaction between COX-2 -765 C carriers and Helicobacter pylori infection and eating pickled vegetables.
Our findings suggest a multi-step process of gene-environment interaction contributes to gastric carcinogenesis.
中国回族有着多样的起源，包括阿拉伯、波斯、中亚和蒙古。回族人群中胃癌的标准化死亡率高于中国总体人群。在本研究中，我们调查了广泛研究的COX-2 -765G>C多态性是否与中国回族人群的胃癌及其癌前病变（GPL）有关。
采用焦磷酸测序法对100例胃癌病例、102例胃癌及其癌前病变病例和105例对照进行COX-2 -765G>C多态性检测。数据采用卡方检验和逻辑回归模型进行统计学分析。
在中国回族人群中，COX-2 -765 C等位基因携带者患胃癌的风险增加（OR=1.977，95%CI=1.104-3.541）。我们还发现COX-2 -765 C携带者与幽门螺杆菌感染和食用腌制蔬菜之间存在相互作用。
我们的研究结果表明，基因-环境相互作用的多步骤过程有助于胃癌的发生。
