Olsson Mia, Frankowiack Marcel, Tengvall Katarina, Roosje Petra, Fall Tove, Ivansson Emma, Bergvall Kerstin, Hansson-Hamlin Helene, Sundberg Katarina, Hedhammar Ake, Lindblad-Toh Kerstin, Hammarström Lennart
Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-75123 Uppsala, Sweden.
Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden.
Vet Immunol Immunopathol. 2014 Aug 15;160(3-4):255-9. doi: 10.1016/j.vetimm.2014.05.010. Epub 2014 May 27.
Immunoglobulin A (IgA) serves as the basis of the secretory immune system by protecting the lining of mucosal sites from pathogens. In both humans and dogs, IgA deficiency (IgAD) is associated with recurrent infections of mucosal sites and immune-mediated diseases. Low concentrations of serum IgA have previously been reported to occur in a number of dog breeds but no generally accepted cut-off value has been established for canine IgAD. The current study represents the largest screening to date of IgA in dogs in terms of both number of dogs (n=1267) and number of breeds studied (n=22). Serum IgA concentrations were quantified by using capture ELISA and were found to vary widely between breeds. We also found IgA to be positively correlated with age (p<0.0001). Apart from the two breeds previously reported as predisposed to low IgA (Shar-Pei and German shepherd), we identified six additional breeds in which ≥ 10% of all tested dogs had very low (<0.07 g/l) IgA concentrations (Hovawart, Norwegian elkhound, Nova Scotia duck tolling retriever, Bullterrier, Golden retriever and Labrador retriever). In addition, we discovered low IgA concentrations to be significantly associated with canine atopic dermatitis (CAD, p<0.0001) and pancreatic acinar atrophy (PAA, p=0.04) in German shepherds.
免疫球蛋白A（IgA）通过保护黏膜部位的内膜免受病原体侵害，构成了分泌性免疫系统的基础。在人类和犬类中，IgA缺乏症（IgAD）都与黏膜部位的反复感染及免疫介导性疾病有关。此前有报道称，多种犬种血清IgA浓度较低，但尚未确立普遍认可的犬类IgAD临界值。就受试犬数量（n = 1267）和所研究犬种数量（n = 22）而言，本研究是迄今为止对犬类IgA进行的规模最大的筛查。采用捕获ELISA法定量血清IgA浓度，发现各犬种间差异很大。我们还发现IgA与年龄呈正相关（p < 0.0001）。除了之前报道的易患低IgA血症的两个犬种（沙皮犬和德国牧羊犬）外，我们还确定了另外六个犬种，其中所有受试犬中≥10%的犬IgA浓度极低（<0.07 g/l）（霍夫瓦尔特犬、挪威猎麋犬、新斯科舍诱鸭寻猎犬、牛头梗、金毛寻回犬和拉布拉多寻回犬）。此外，我们发现德国牧羊犬的低IgA浓度与犬异位性皮炎（CAD，p < 0.0001）和胰腺腺泡萎缩（PAA，p = 0.04）显著相关。
