Abdel-Mannan Omar, Sutcliffe Alastair
General and Adolescent Paediatric Unit, Institute of Child Health, London, UK.
General and Adolescent Paediatric Unit, Institute of Child Health, London, UK.
Semin Fetal Neonatal Med. 2014 Aug;19(4):245-9. doi: 10.1016/j.siny.2014.04.003. Epub 2014 Jun 13.
With an ever-expanding population of children born after in-vitro fertilisation (IVF), the widespread use of assisted reproductive techniques (ART) has placed a great emphasis on the need to study their long-term outcomes. Indeed, there has been concern that mechanisms used in ART may have a detrimental effect on the neurocognitive development of these children. Reassuringly, most neurocognitive and motor development studies using various assessment scales have generally found no differences between intracytoplasmic sperm injection, IVF and naturally conceived children. Only a few studies have reported concerns. In terms of predictors of intelligence in children, ART appears to have a minimal effect in comparison to birth weight, gestational age, socio-economic status, and parental educational levels. Nevertheless, further research of higher methodological quality in children beyond pre-school age and on newer ART procedures is needed.
随着体外受精(IVF)后出生的儿童数量不断增加,辅助生殖技术(ART)的广泛应用使得对其长期结果的研究需求变得极为迫切。确实,有人担心ART所使用的机制可能会对这些儿童的神经认知发育产生不利影响。令人欣慰的是,大多数使用各种评估量表的神经认知和运动发育研究普遍发现,卵胞浆内单精子注射、IVF与自然受孕的儿童之间没有差异。只有少数研究报告了相关担忧。就儿童智力的预测因素而言,与出生体重、胎龄、社会经济地位和父母教育水平相比,ART似乎影响极小。然而,仍需要对学龄前以上儿童以及更新的ART程序进行更高质量方法学的进一步研究。