Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, 7624 Pécs, Hungary.
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran.
Int J Mol Sci. 2023 Sep 1;24(17):13564. doi: 10.3390/ijms241713564.
Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences.
辅助生殖技术（ART）显著提高了不孕夫妇成功妊娠和活产的机会。ART 的不同程序，包括体外受精（IVF）、胞浆内精子注射（ICSI）、宫腔内人工授精（IUI）和配子输卵管内移植（GIFT），被广泛用于克服与不孕相关的问题。尽管其具有不可否认的用处，但人们对 ART 受孕婴儿的健康后果表示担忧。有报道称，ART 与出生缺陷和健康并发症有关，例如恶性肿瘤、高血压、全身血管功能障碍、哮喘和代谢紊乱等。有人认为，母亲的激素治疗以及配子和胚胎操作过程中的人工环境可能导致基因组和表观遗传改变，从而对 ART 受孕婴儿的健康状况产生后续并发症。在本研究中，我们旨在综述不同 ART 程序对 ART 受孕后代后续健康状况的可能长期影响，同时考虑可能导致长期后果的混杂因素。
