Ramadan H H, Schuknecht H F
Department of Otolaryngology, Harvard Medical School, Boston, MA.
Otolaryngol Head Neck Surg. 1989 Jan;100(1):30-4. doi: 10.1177/019459988910000105.
Many ears that manifest hearing losses caused by aging show combinations of atrophic change in the sensory cells, cochlear neurons, and stria vascularis. When it occurs in pure form, the loss of sensory cells produces an abruptly sloping high-tone threshold loss, the loss of cochlear neurons decreases the capability for speech discrimination, and the loss of strial tissue produces a flat threshold loss. There remains a fourth group of cases that have gradual sloping high-tone threshold losses for which a pathological correlate has not been identified. We performed a quantitative histologic study, using light microscopy on the temporal bones of such cases, and again could find no pathologic explanation. We believe that the findings of this study support the concept of an alteration in cochlear motion mechanics as the most probable cause for the gradually sloping high-tone hearing loss.
许多因衰老而出现听力损失的耳朵表现出感觉细胞、耳蜗神经元和血管纹的萎缩性变化的组合。当以纯形式出现时,感觉细胞的丧失会导致突然倾斜的高音阈值损失,耳蜗神经元的丧失会降低语音辨别能力,而血管纹组织的丧失会产生平坦的阈值损失。还有第四组病例,其高音阈值损失呈逐渐倾斜,尚未确定其病理相关性。我们对这些病例的颞骨进行了定量组织学研究,采用光学显微镜观察,同样未找到病理原因。我们认为,本研究结果支持耳蜗运动力学改变是逐渐倾斜的高音听力损失最可能原因的概念。