长链非编码RNA在神经元发育和疾病中的依赖性转录调控
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease.
作者信息
Clark Brian S, Blackshaw Seth
机构信息
Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of Ophthalmology, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Center for High-Throughput Biology, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Institute for Cell Engineering, Johns Hopkins University School of Medicine Baltimore, MD, USA.
出版信息
Front Genet. 2014 Jun 6;5:164. doi: 10.3389/fgene.2014.00164. eCollection 2014.
Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development and disease. In this review, we discuss new findings implicating lncRNAs in controlling development of the central nervous system (CNS). The evolution of the higher vertebrate brain has been accompanied by an increase in the levels and complexities of lncRNAs expressed within the developing nervous system. Although a limited number of CNS-expressed lncRNAs are now known to modulate the activity of proteins important for neuronal differentiation, the function of the vast majority of neuronal-expressed lncRNAs is still unknown. Topics of intense current interest include the mechanism by which CNS-expressed lncRNAs might function in epigenetic and transcriptional regulation during neuronal development, and how gain and loss of function of individual lncRNAs contribute to neurological diseases.
对哺乳动物转录组的综合分析表明，长链非编码RNA（lncRNAs）可能在细胞转录物中占很大一部分。近年来，旨在从功能上表征lncRNAs在发育和疾病中作用的研究激增。在本综述中，我们讨论了有关lncRNAs参与控制中枢神经系统（CNS）发育的新发现。高等脊椎动物大脑的进化伴随着发育中的神经系统中lncRNAs表达水平和复杂性的增加。虽然目前已知有限数量的中枢神经系统表达的lncRNAs可调节对神经元分化重要的蛋白质的活性，但绝大多数神经元表达的lncRNAs的功能仍然未知。当前研究热点包括中枢神经系统表达的lncRNAs在神经元发育过程中可能在表观遗传和转录调控中发挥作用的机制，以及单个lncRNAs的功能获得和丧失如何导致神经疾病。
Zotero 插件