Arlen Myron, Arlen Philip, Coppa Gene, Crawford Jim, Wang XuePing, Saric Olga, Dubeykovskiy Alex, Molmenti Ernesto
Myron Arlen, Gene Coppa, Jim Crawford, Ernesto Molmenti, Department of Surgery, Division of Surgical Oncology and the Dept. of Pathology, North Shore University Hospital, Manhasset, NY 11030, United States.
World J Gastrointest Oncol. 2014 Jun 15;6(6):170-6. doi: 10.4251/wjgo.v6.i6.170.
In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeutic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired improvements that have been sought after. Adjuvant therapy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demonstrated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific monoclonals targeting colorectal cancer are employed diagnostically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted.
为了改善结直肠癌的治疗最终效果，很明显，诊断越早，获得理想结果的机会就越大。对于以晚期结直肠癌为代表的更晚期肿瘤，手术减瘤是治疗策略的重要组成部分。在此，包括化疗和当今免疫疗法在内的其他治疗方式的使用未能实现所追求的理想改善。辅助治疗对总体生存率贡献不大。早期检测的概念现在被认为是达成适当最终结果的第一步，并且可以从结直肠癌研究中很容易地得到证明。在此已发现生存率是首次识别和治疗肿瘤阶段的反映。当将靶向结直肠癌的特异性单克隆抗体用于诊断时，我们已经能够在结直肠癌作为癌前病变开始时就检测到它，从而在能够注意到癌症的表型出现之前就识别出基因型特征。
