Farsi Payam Farahbakhsh, Djazayery Abolghassem, Eshraghian Mohammad Reza, Koohdani Fariba, Saboor-Yaraghi Ali Akbar, Derakhshanian Hoda, Zarei Mahnaz, Javanbakht Mohammad Hassan, Djalali Mahmoud
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Arq Bras Endocrinol Metabol. 2014 Jun;58(4):335-40. doi: 10.1590/0004-2730000002861.
The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients.
Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study.
Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05).
Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations.
本研究旨在确定补充ω-3对2型糖尿病患者非酯化脂肪酸（NEFA）浓度、胰岛素敏感性和抵抗以及糖脂代谢的作用。
44名2型糖尿病患者被随机分为两组。A组每天服用4克ω-3软胶囊，B组服用安慰剂，为期10周。禁食12小时后采集血样。在研究开始和结束时，从所有参与者处获取身体活动记录、三天饮食记录和人体测量数据。
与安慰剂组相比，补充ω-3使干预组的NEFA显著降低（P = 0.009）。此外，与安慰剂组相比，ω-3的给药使干预组在胰岛素和Quicki指数等各种参数上有显著更大的变化（差异）（P < 0.05）。
2型糖尿病患者补充ω-3脂肪酸可改善胰岛素敏感性，可能是由于NEFA浓度降低。
