补充ω-3对2型糖尿病患者胰岛素敏感性和非酯化游离脂肪酸（NEFA）的影响。

Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients.

作者信息

Farsi Payam Farahbakhsh, Djazayery Abolghassem, Eshraghian Mohammad Reza, Koohdani Fariba, Saboor-Yaraghi Ali Akbar, Derakhshanian Hoda, Zarei Mahnaz, Javanbakht Mohammad Hassan, Djalali Mahmoud

机构信息

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Arq Bras Endocrinol Metabol. 2014 Jun;58(4):335-40. doi: 10.1590/0004-2730000002861.

DOI:10.1590/0004-2730000002861

PMID:24936727

Abstract

OBJECTIVE

The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients.

SUBJECTS AND METHODS

Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study.

RESULTS

Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05).