Gao Huanqing, Geng Tingting, Huang Tao, Zhao Qinghua
Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Epidemiology Domain, Saw Swee Hock School of Public Health, Singapore, Singapore.
Lipids Health Dis. 2017 Jul 3;16(1):131. doi: 10.1186/s12944-017-0528-0.
Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity.
We searched the Cochrane Library, PubMed, Embase database for the relevant studies update to Dec 2016. Two researchers screened the literature independently by the selection and exclusion criteria. Studies were pooled using random effect models to estimate a pooled SMD and corresponding 95% CI. This meta-analysis was performed by Stata 13.1 software.
A total of 17 studies with 672 participants were included in this meta-analysis study after screening from 498 published articles found after the initial search. In a pooled analysis, fish oil supplementation had no effects on insulin sensitivity compared with the placebo (SMD 0.17, 95%CI -0.15 to 0.48, p = 0.292). In subgroup analysis, fish oil supplementation could benefit insulin sensitivity among people who were experiencing at least one symptom of metabolic disorders (SMD 0.53, 95% CI 0.17 to 0.88, p < 0.001). Similarly, there were no significant differences between subgroups of methods of insulin sensitivity, doses of omega-3 polyunsaturated fatty acids (n-3 PUFA) of fish oil supplementation or duration of the intervention. The sensitivity analysis indicated that the results were robust.
Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders.
补充鱼油已被证明与较低的代谢综合征风险相关，并有益于多种慢性疾病，如心血管疾病、2型糖尿病和几种癌症。然而，补充鱼油对葡萄糖代谢和胰岛素敏感性的证据仍存在争议。本荟萃分析总结了补充鱼油与胰岛素敏感性之间关系的现有证据，旨在评估补充鱼油是否能改善胰岛素敏感性。
我们检索了考克兰图书馆、PubMed、Embase数据库，以获取截至2016年12月的相关研究。两名研究人员根据纳入和排除标准独立筛选文献。采用随机效应模型对研究进行合并，以估计合并标准化均数差（SMD）及相应的95%置信区间（CI）。本荟萃分析使用Stata 13.1软件进行。
在初步检索后找到的498篇已发表文章中筛选出17项研究，共672名参与者纳入本荟萃分析。在合并分析中，与安慰剂相比，补充鱼油对胰岛素敏感性无影响（SMD 0.17，95%CI -0.15至0.48，p = 0.292）。在亚组分析中，补充鱼油可使至少有一项代谢紊乱症状的人群的胰岛素敏感性受益（SMD 0.53，95%CI 0.17至0.88，p < 0.001）。同样，胰岛素敏感性方法亚组、补充鱼油的ω-3多不饱和脂肪酸（n-3 PUFA）剂量亚组或干预持续时间亚组之间均无显著差异。敏感性分析表明结果稳健。
短期补充鱼油与提高代谢紊乱人群的胰岛素敏感性有关。
