Giuffrida Giuseppe, Giovinazzo Salvatore, Certo Rosaria, Vicchio Teresa Manuela, Baldari Sergio, Campennì Alfredo, Ruggeri Rosaria Maddalena
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Italy.
Department of Biomedical Sciences and of Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, Italy.
Arq Bras Endocrinol Metabol. 2014 Jun;58(4):398-401. doi: 10.1590/0004-2730000003173.
The term Marine-Lenhart syndrome describes the association between Graves' disease and autonomously functioning thyroid nodules (AFTN), such as toxic adenoma or toxic multinodular goiter. The two diseases may coexist or may be present at different moments in the same patient. In the literature, there are many reports on the development of Graves' disease after radioiodine treatment for AFTN, but very little information may be found on the occurrence of AFTN after radioiodine therapy for Graves' disease. We describe here the case of a female patient with Graves' disease who was successfully treated with radioiodine for Graves' disease, returning to normal thyroid function. Three years later, biochemical analysis and ultrasound examination identified a thyroid nodule that progressively increased in size. The 99mTc-pertechnetate scintigraphy showed avid uptake in the right lobule, which corresponded to a nodular lesion consistent with AFTN.
“Marine-Lenhart综合征”指的是格雷夫斯病与自主功能性甲状腺结节（AFTN）之间的关联，如毒性腺瘤或毒性多结节性甲状腺肿。这两种疾病可能同时存在，也可能在同一患者的不同时期出现。在文献中，有许多关于放射性碘治疗AFTN后发生格雷夫斯病的报道，但关于放射性碘治疗格雷夫斯病后发生AFTN的信息却很少。我们在此描述一例格雷夫斯病女性患者，她接受放射性碘成功治疗格雷夫斯病后，甲状腺功能恢复正常。三年后，生化分析和超声检查发现一个甲状腺结节，其大小逐渐增大。99mTc-高锝酸盐闪烁扫描显示右叶有明显摄取，这与一个符合AFTN的结节性病变相对应。
