Int J Psychiatry Clin Pract. 2001;5(1):19-26. doi: 10.1080/136515001300224854.
Quality of life (QoL) was evaluated in 100 schizophrenic patients treated with classic or atypical neuroleptics in a day hospital. The severity of schizophrenia was evaluated with the PANSS scale and QoL with the SF36 questionnaire. Both the patients' global QoL and several QoL domains improved after treatment. The QoL of female and male patients did not differ at baseline, but the improvement after treatment was greater in female patients, and in female patients the QoL improvement correlated positively with the improvement in PANSS general symptoms. The severity of depressive symptoms of schizophrenic patients correlated inversely with the total QoL, at both the start and end of the study. The improvement of general schizophrenic and depressive symptoms correlated positively with the improvement in QoL. The improvement in QoL in patients treated with classic neuroleptics differed only insignificantly after treatment, in comparison to that in patients receiving 'old' atypical drugs. However, the negative correlation between QoL improvement and improvement in PANSS total score, as well as in PANSS depressive symptoms, was found only among patients treated with classic neuroleptics. Neuroleptic-induced extrapyramidal symptoms were more severe in patients receiving classic neuroleptics but these did not have an impact on patients' QoL. ( Int J Psych Clin Pract 2001; 5:19-26).
在日间医院中，100 名接受经典或非典型神经安定药治疗的精神分裂症患者的生活质量（QoL）得到了评估。采用 PANSS 量表评估精神分裂症的严重程度，采用 SF36 问卷评估 QoL。治疗后，患者的整体 QoL 和几个 QoL 领域都得到了改善。治疗前，男女患者的 QoL 并无差异，但女性患者治疗后的改善幅度更大，且女性患者的 QoL 改善与 PANSS 一般症状的改善呈正相关。精神分裂症患者的抑郁症状严重程度与总 QoL 呈负相关，无论是在研究开始还是结束时均如此。一般精神分裂症和抑郁症状的改善与 QoL 的改善呈正相关。与接受“旧”非典型药物治疗的患者相比，接受经典神经安定药治疗的患者在治疗后的 QoL 改善仅略有差异。然而，只有接受经典神经安定药治疗的患者才发现 QoL 改善与 PANSS 总分以及 PANSS 抑郁症状改善之间存在负相关。经典神经安定药引起的锥体外系症状在接受经典神经安定药治疗的患者中更为严重，但这些症状并未对患者的 QoL 产生影响。（国际精神病临床实践杂志 2001 年；5：19-26）。
