Jarema M, Konieczyńska Z
III Kliniki Psychiatrycznej IPiN w Warszawie.
Psychiatr Pol. 2000 Mar-Apr;34(2):275-88.
Subjective health-related quality of life was evaluated in 100 patients from day-hospital, treated for schizophrenia with classical (perazine, perphenazine, zuclopenthixol) or "old" atypical (klozapine, sulpiride) neuroleptics. No correlation was found between the clinical improvement (PANSS scale) and the quality of life (SF-36). After the treatment the improvement of the quality of life was significantly better in female than in male patients. In women more correlations were found between clinical improvement after treatment and the of quality of life domains. The general subjective health-related quality of life after treatment with classical and "old" atypical drugs did not differ. After the treatment those patients who received classical neuroleptics reported more physical complains but better improvement in the domain "role-emotional" than the subjects treated with "old" atypical drugs. Significant clinical improvement was found in patients treated with perazine, perphenazine and zuclopenthixol but not with clozapine or sulpiride. The presence and intensity of neuroleptic side-effects did not correlate with the quality of life. In patients who had more pronounced neuroleptic side-effects less favorable improvement was found in regard to those quality of life domains which included physical status as well as the evaluation of patients' mental health.
对日间医院的100例使用经典（奋乃静、奋乃静、氯普噻吨）或“老”非典型（氯氮平、舒必利）抗精神病药物治疗精神分裂症的患者进行了主观健康相关生活质量评估。未发现临床改善（阳性和阴性症状量表）与生活质量（SF - 36）之间存在相关性。治疗后，女性患者的生活质量改善明显优于男性患者。在女性中，治疗后的临床改善与生活质量领域之间发现了更多相关性。使用经典和“老”非典型药物治疗后的总体主观健康相关生活质量没有差异。治疗后，接受经典抗精神病药物治疗的患者报告的身体不适更多，但在“角色 - 情感”领域的改善比使用“老”非典型药物治疗的受试者更好。使用奋乃静、奋乃静和氯普噻吨治疗的患者有显著的临床改善，但使用氯氮平或舒必利治疗的患者没有。抗精神病药物副作用的存在和强度与生活质量无关。在有更明显抗精神病药物副作用的患者中，在包括身体状况以及患者心理健康评估的生活质量领域中发现的改善不太理想。
