Fukuoka University.
Int J Psychiatry Clin Pract. 2003;7 Suppl 1:23-4. doi: 10.1080/13651500310000861.
Pain and depression are thought to arise from a common neurochemical dysfunction at the level of noradrenergic and serotonergic neurons, and antidepressants are used to treat chronic pain. The dual action tricyclic antidepressants are more potent in relieving pain than the selective serotonin reuptake inhibitors. Glossodynia is chronic pain and burning sensation in the tongue often associated with depression. Patients suffering from glossodynia were treated with the serotonin and noradrenaline reuptake inhibitor, milnacipran, which has been recently launched in Japan. Milnacipran was found to be effective in the relief of the chronic glossodynia and well tolerated.
疼痛和抑郁被认为是由于去甲肾上腺素能和 5-羟色胺能神经元的共同神经化学功能障碍引起的，而抗抑郁药被用于治疗慢性疼痛。双相三环抗抑郁药在缓解疼痛方面比选择性 5-羟色胺再摄取抑制剂更有效。舌灼痛是一种慢性疼痛和舌烧灼感，常与抑郁有关。患有舌灼痛的患者接受了最近在日本上市的 5-羟色胺和去甲肾上腺素再摄取抑制剂米那普仑的治疗。研究发现，米那普仑能有效缓解慢性舌灼痛，且耐受性良好。
