葡萄膜黑色素瘤中的 GNAQ/11 突变：YAP 是否是靶向治疗的关键？
GNAQ/11 mutations in uveal melanoma: is YAP the key to targeted therapy?
机构信息
Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
出版信息
Cancer Cell. 2014 Jun 16;25(6):714-5. doi: 10.1016/j.ccr.2014.05.028.
Abstract
GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.
摘要
GNAQ 和 GNA11 在葡萄膜黑色素瘤中经常发生突变，但它们仍然是难以治疗的靶点。在本期《癌细胞》杂志中，Feng 和他的同事们以及 Yu 和他的同事们证明，突变型 GNAQ/11 的致癌活性至少部分是通过 YAP 介导的，这可能揭示了一种新的治疗策略。
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Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.突变 Gq/11 通过激活 YAP 促进葡萄膜黑色素瘤的发生。
Cancer Cell. 2014 Jun 16;25(6):822-30. doi: 10.1016/j.ccr.2014.04.017. Epub 2014 May 29.
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Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.GNAQ 葡萄膜黑素瘤癌基因通过 trio 调控的 rho GTP 酶信号通路非 Hippo 依赖性激活 YAP。
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