Scholtes Vincent P W, Peeters Wouter, van Lammeren Guus W, Howard Dominic P J, de Vries Jean-Paul P M, de Borst Gert Jan, Redgrave Jessica N, Kemperman Hans, Schalkwijk Casper G, den Ruijter Hester M, de Kleijn Dominique P V, Moll Frans L, Rothwell Peter M, Pasterkamp Gerard
Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Department of Clinical Neurology, Stroke Prevention Research Unit, Radcliffe Infirmary, Oxford, UK.
Atherosclerosis. 2014 Aug;235(2):418-23. doi: 10.1016/j.atherosclerosis.2014.05.941. Epub 2014 Jun 3.
Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce.
We used one of the largest biobanks, the Athero-Express study (n=1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients.
In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
糖尿病会加速动脉粥样硬化疾病的进展，但关于糖尿病与晚期动脉粥样硬化斑块成分之间关联的数据却很稀少。
我们采用了最大的生物样本库之一，即颈动脉内膜切除术（CEA）中的动脉粥样硬化表达研究（Athero-Express study，n = 1455）。对所有斑块进行组织学分析，以评估脂质核心大小、胶原蛋白、巨噬细胞、平滑肌细胞、微血管密度和钙化情况。此外，还对一部分患者的细胞因子和趋化因子进行了评估。与非2型糖尿病患者相比，295例（20%）2型糖尿病患者既往心血管干预的比例更高，对高血压和高胆固醇血症的治疗也更为严格。令人惊讶的是，未观察到糖尿病与组织学斑块特征之间存在关联。此外，在糖尿病患者和非糖尿病患者的斑块中，炎症趋化因子、细胞因子或晚期糖基化终产物的表达也未观察到差异。
在患有严重颈动脉疾病的患者中，糖尿病似乎与特定的动脉粥样硬化斑块特征无关。
