a Ochsner Health Systems, Radiation Oncology, New Orleans, Louisiana and.
Radiat Res. 2014 Jul;182(1):72-82. doi: 10.1667/RR13558.1. Epub 2014 Jun 17.
Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources. The influence of cell parameters of linear-quadratic survival, repair function and proliferation rate, as well as the influence of dose rate, isotopic decay rate and linear energy transfer (LET) quality on cell killing are displayed and discussed. An expression for biologic effective dose (BED) is presented that facilitates comparison of the effects of protracted low-dose-rate irradiation and with a course of multiple instantaneously administered radiation treatments (fractions).
基于微剂量动力学模型的关系被提出，用于计算哺乳动物细胞在临时和永久性植入放射性源的持续照射下产生的平均致死损伤数和相关的细胞存活率。展示和讨论了细胞参数（线性二次存活、修复功能和增殖率）以及剂量率、同位素衰变率和线性能量传递（LET）质量对细胞杀伤的影响。提出了生物有效剂量（BED）的表达式，方便比较长时间低剂量率照射和多次瞬间给予放射治疗（分次）的效果。
