McMahon Stephen J, Prise Kevin M
Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, UK.
Cancers (Basel). 2019 Feb 10;11(2):205. doi: 10.3390/cancers11020205.
Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.
几十年来，放射生物学建模一直是放射生物学和放射治疗的关键组成部分，临床实践的许多方面都由线性二次模型等工具指导。然而，常规临床使用的大多数模型都是抽象的和经验性的，在新的细胞系或治疗方法中，它们没有为机理解释或预测提供很大的空间。在本综述中，我们将讨论放射生物学中正在进行的机理研究的关键领域，包括物理、化学和生物学步骤，并综述在每个领域应用的一系列机理建模方法，突出这些技术带来的可能机遇和挑战。
