Seckin Berna, Turkcapar Figen, Yildiz Yunus, Senturk Bahar, Yilmaz Nafiye, Gulerman Cavidan
J Reprod Med. 2014 May-Jun;59(5-6):260-6.
To investigate the effect of luteal phase support with vaginal progesterone on pregnancy rates of the gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients with unexplained infertility with regard tofollicular growth.
A total of 149 patients with unexplained infertility who underwent 166 recombinant follicle stimulated hormone--stimulated IUI cycles were prospectively randomized into 2 groups for luteal phase support. The study group (n = 71) received vaginal progesterone gel supplementation, and the control group (n = 78) received no drug for luteal support. The clinical pregnancy rates and live birth rates per cycle and per patient were compared between the groups.
The differences between the groups with regard to clinical pregnancy rates and live birth rates per patient or per cycle were not different among all patients. In cycles with > 1 dominant follicle (multifollicular response), the clinical pregnancy rate per patient was significantly higher in the supported cycles as compared with the unsupported cycles (28.2% vs. 11.4%, respectively, p = 0.04). Reproductive outcomes in cycles with a single dominant follicle (monofollicular response) were not different between supported and unsupported cycles.
Luteal phase support with vaginal progesterone affects the success of gonadotropin-stimulated IUI cycles with multifollicular response but not with monofollicular response.
探讨在不明原因不孕症患者中，就卵泡生长而言，阴道用黄体酮进行黄体期支持对促性腺激素刺激的宫腔内人工授精（IUI）周期妊娠率的影响。
总共149例不明原因不孕症患者接受了166个重组促卵泡激素刺激的IUI周期，被前瞻性随机分为2组进行黄体期支持。研究组（n = 71）接受阴道用黄体酮凝胶补充治疗，对照组（n = 78）未接受黄体支持药物治疗。比较两组之间每个周期和每位患者的临床妊娠率和活产率。
在所有患者中，两组之间每位患者或每个周期的临床妊娠率和活产率差异无统计学意义。在有>1个优势卵泡（多卵泡反应）的周期中，接受支持治疗的周期中每位患者临床妊娠率显著高于未接受支持治疗的周期（分别为28.2%对11.4%，p = 0.04）。有单个优势卵泡（单卵泡反应）的周期中，接受支持治疗和未接受支持治疗的周期生殖结局无差异。
阴道用黄体酮进行黄体期支持对多卵泡反应的促性腺激素刺激的IUI周期成功率有影响，但对单卵泡反应的周期无影响。
