Koller Heiko, Meier Oliver, Hitzl Wolfgang
Center for Spine Surgery, Werner-Wicker-Klinik, Im Kreuzfeld 4, 34537, Bad Wildungen, Germany,
Eur Spine J. 2014 Dec;23(12):2658-71. doi: 10.1007/s00586-014-3405-9. Epub 2014 Jun 18.
Failure to select the appropriate lowest instrumented vertebra (LIV) in selective lumbar fusion (SLF) for thoracolumbar/lumbar curves (LC) can result in adding-on in the lumbar curve (LC) or the need for fusion extension due to a decompensating thoracic curve (TC). The selection criteria that predict optimal outcomes still need to be refined. The objectives of the current study were to identify risk factors for failure of anterior scoliosis correction and fusion (ASF) as well as predictors of optimal outcomes and ASF efficacy for SLF.
A retrospective review of all patients (n = 245) with AIS who had anterior SLF at one institution was conducted. Optimal outcomes were defined as a target LC ≤ 20° and a target TC ≤ 30°. The distance from the LIV to the SV was recorded. An increase in the LIV adjacent level disc angulation (LIVDA) ≥ 5° was defined as adding-on. An increase in the TC at follow-up was defined as TC-progression. Stepwise univariate and multivariate linear and logistic regression analyses were performed to identify criteria predicting the target LC and TC. A total of 68 % of the patients had the LIV at SV-2 (=2 levels above stable vertebra).
The patients' average age was 17 years, the average fusion length was 4.6 levels, and the average follow-up time was 32 months. The preoperative LC was 49 ± 14°, the LC-bending was 22 ± 13° (57 ± 18 %), and the follow-up LC was 25 ± 10°. LC correction was 59 ± 17% (p < 0.01). The preoperative TC was 39 ± 13°, the TC-bending was 21 ± 12°, and the follow-up TC was 29 ± 13°. The TC-correction was 32 ± 19% (p < 0.01). At follow-up, 85 patients (35%) had an LC ≤ 20°, 110 patients (45 %) had a TC ≤ 30°. The follow-up LC and an LC ≤ 20° were predicted by LC-bending (p < 0.01, r = 0.6), preoperative LC (p < 0.01, r = 0.6). The logistic regression models could define patients at risk for failing the target LC ≤ 20° or TC ≤ 30°. At follow-up, TC ≤ 30° was best predicted by the preoperative TC (p < 0.01, r = 0.8; OR 1.2) and TC-bending (p < 0.01, r = 0.8; OR 1.06), with the logistic regression model revealing a correct prediction in 84 % of all cases. Among the patients, 8 % required late posterior surgery. Patients achieving the target LC ≤ 20° had a significantly reduced risk for failure (p = 0.01). Selecting an LIV at SV-1 vs. SV-2 significantly increased the chance of achieving a target LC ≤ 20° (p = 0.01) and reduced the risk of adding-on (p < 0.01). Predictors for failure also included a high preoperative LC (p = 0.02; OR 0.97), TC-bending (p < 0.01), and preoperative TC (p = 0.01). A cut-off in the failure risk analysis was established at a TC of 38°. Additionally, a significant cut-off for risk of adding-on was established at LIVDA <3.5°.
A high chance of achieving a target LC ≤ 20° and a low risk of revision was dependent on LC-bending, preoperative LC and TC, and a LIV at SV-1 with non-parallel LIVDA. Our risk model analysis may support the selection of a safe LIV to achieve the target LC.
在胸腰段/腰椎侧弯(LC)的选择性腰椎融合术(SLF)中,未能选择合适的最低融合椎体(LIV)可能会导致腰椎侧弯(LC)进展,或者由于胸椎侧弯(TC)失代偿而需要延长融合节段。预测最佳手术效果的选择标准仍有待完善。本研究的目的是确定前路脊柱侧弯矫正融合术(ASF)失败的危险因素,以及SLF达到最佳手术效果和ASF疗效的预测因素。
对在同一机构接受前路SLF治疗的所有特发性脊柱侧弯(AIS)患者(n = 245)进行回顾性研究。最佳手术效果定义为目标LC≤20°且目标TC≤30°。记录LIV到稳定椎体(SV)的距离。LIV相邻节段椎间盘角度增加(LIVDA)≥5°定义为进展。随访时TC增加定义为TC进展。进行逐步单因素和多因素线性及逻辑回归分析,以确定预测目标LC和TC的标准。共有68%的患者LIV位于SV - 2(=稳定椎体上方2个节段)。
患者平均年龄17岁,平均融合节段数为4.6个,平均随访时间为32个月。术前LC为49±14°,LC弯曲度为22±13°(57±18%),随访时LC为25±10°。LC矫正率为59±17%(p < 0.01)。术前TC为39±13°,TC弯曲度为21±12°,随访时TC为29±13°。TC矫正率为32±19%(p < 0.01)。随访时,85例患者(35%)的LC≤20°,110例患者(45%)的TC≤30°。随访时的LC及LC≤20°可通过LC弯曲度(p < 0.01,r = 0.6)、术前LC(p < 0.01,r = 0.6)预测。逻辑回归模型可以确定目标LC≤20°或TC≤30°失败风险的患者。随访时,术前TC(p < 0.01,r = 0.8;OR 1.2)和TC弯曲度(p < 0.01,r = 0.8;OR 1.06)对TC≤30°的预测最佳,逻辑回归模型在所有病例中的正确预测率为84%。在这些患者中,8%需要二期后路手术。达到目标LC≤20°的患者失败风险显著降低(p = 0.01)。选择SV - 1而非SV - 2的LIV显著增加了达到目标LC≤20°的机会(p = 0.01)并降低了进展风险(p < 0.01)。失败的预测因素还包括术前LC高(p = 0.02;OR 0.97)、TC弯曲度(p < 0.01)和术前TC(p = 0.01)。在失败风险分析中,将TC为38°作为截断值。此外,将LIVDA < 3.5°作为进展风险的显著截断值。
达到目标LC≤20°的高概率和低翻修风险取决于LC弯曲度、术前LC和TC,以及SV - 1处的LIV且LIVDA不平行。我们的风险模型分析可能有助于选择安全的LIV以实现目标LC。