Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ann Rheum Dis. 2015 Nov;74(11):1983-9. doi: 10.1136/annrheumdis-2014-205375. Epub 2014 Jun 17.
Epidemiological studies of primary Sjögren's syndrome (pSS) are crucial for describing the burden to society and the public medical system and for shedding light on aetiology. Previous reports of the epidemiology of pSS show variable outcomes. We conducted a systematic review of the epidemiology of pSS to assess the prevalence rates (PRs) and incidence rates (IRs), and to investigate possible geographic variations in pSS.
A systematic literature search of PubMed and Embase (updated to 22 October 2013) was performed to identify all published reports on the epidemiology of pSS. The incidence and prevalence rates of pSS were summarised with IRs or PRs and 95% CIs.
The literature search yielded 1880 related citations. Only 21 fulfilled the inclusion criteria. According to a random-effects model, the pooled IR for pSS was 6.92 (95% CI 4.98 to 8.86) per 100 000 person-years. The overall PR was 60.82 (95% CI 43.69 to 77.94) cases per 100 000 inhabitants with a slightly lower estimate of Baodong Qin is BDQ, Jiaqi Wang is JQW, Zaixing Yang is ZXY, Renqian Zhong is RQZ. 43.03 (25.74 to 60.31) cases per 100 000 inhabitants when only considering population-based studies. The female/male ratio in incidence data was 9.15 (95% CI 3.35 to 13.18). The female/male ratio in prevalence data was 10.72 (95% CI 7.35 to 15.62). The overall age of pSS patients was 56.16 years (95% CI 52.54 to 59.78).
Incidence and prevalence rates of pSS vary widely around the world. The results help us better understand the global epidemiology of pSS. Large population-based studies combining meticulous case-finding and case-ascertainment strategies are needed.
原发性干燥综合征（pSS）的流行病学研究对于描述对社会和公共医疗系统的负担以及阐明病因至关重要。之前关于 pSS 流行病学的报告结果存在差异。我们进行了一项 pSS 流行病学的系统综述，以评估患病率（PRs）和发病率（IRs），并调查 pSS 可能存在的地理差异。
对 PubMed 和 Embase 进行了系统的文献检索（更新至 2013 年 10 月 22 日），以确定所有关于 pSS 流行病学的已发表报告。使用发病率（IR）或患病率（PR）和 95%置信区间（CI）来总结 pSS 的发病率和患病率。
文献检索产生了 1880 篇相关引文。只有 21 篇符合纳入标准。根据随机效应模型，pSS 的汇总发病率为每 100000 人年 6.92（95%CI 4.98 至 8.86）。总患病率为每 100000 居民 60.82（95%CI 43.69 至 77.94）例，当仅考虑基于人群的研究时，患病率略低，为每 100000 居民 43.03（25.74 至 60.31）例。发病率数据中的女性/男性比例为 9.15（95%CI 3.35 至 13.18）。患病率数据中的女性/男性比例为 10.72（95%CI 7.35 至 15.62）。pSS 患者的总体年龄为 56.16 岁（95%CI 52.54 至 59.78）。
pSS 的发病率和患病率在世界各地差异很大。这些结果有助于我们更好地了解全球 pSS 的流行病学。需要进行大型基于人群的研究，结合细致的病例发现和病例确定策略。
