Yokota Takafumi, Kanakura Yuzuru
Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan,
Int J Hematol. 2014 Sep;100(3):238-45. doi: 10.1007/s12185-014-1602-2. Epub 2014 Jun 18.
A great many transcription factors, cytokines, and cytokine receptors have been identified as indispensable elements in lymphocyte differentiation, but the molecular mechanism that orchestrates the expression and function of these molecular factors is unknown. The process of lymphocyte differentiation involves both the simultaneous activation of lymphoid-related genes and the inactivation of non-lymphoid lineage-related genes, suggesting that there should be critical molecules that regulate such gene expression in both temporal and spatial dimensions. Recent studies of chromatin-remodeling proteins shed light on this complex process. In particular, special AT-rich sequence-binding protein 1 has been studied extensively. In this article, we review the wealth of information characterizing this protein.
许多转录因子、细胞因子和细胞因子受体已被确定为淋巴细胞分化中不可或缺的元素，但协调这些分子因子表达和功能的分子机制尚不清楚。淋巴细胞分化过程涉及淋巴相关基因的同时激活和非淋巴谱系相关基因的失活，这表明应该存在在时间和空间维度上调节此类基因表达的关键分子。最近对染色质重塑蛋白的研究为这一复杂过程提供了线索。特别是，富含AT序列的特殊结合蛋白1已得到广泛研究。在本文中，我们综述了有关该蛋白的丰富信息。
