主链保护肽的自动化合成
Automated synthesis of backbone protected peptides.
作者信息
Abdel-Aal Abu-Baker M, Papageorgiou George, Quibell Martin, Offer John
机构信息
MRC National Institiute for Medical Research, The Ridgeway, London, UK.
出版信息
Chem Commun (Camb). 2014 Aug 7;50(61):8316-9. doi: 10.1039/c4cc03065f.
Abstract
The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences.
摘要
富含易于聚集序列的肽的合成可通过主链保护得到改善。我们报告了一种将主链保护自动引入肽的方法。这种新方法应用于全自动合成中，改善了几种具有挑战性的目标序列的处理、质量和产率。
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