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来源于海洋疣孢菌属Verrucosispora sp. FIM06054的化合物及其潜在抗肿瘤活性。

Compounds from marine-derived Verrucosispora sp. FIM06054 and their potential antitumour activities.

作者信息

Yi-Lei Nie, Yun-Dan Wu, Chuan-Xi Wang, Ru Lin, Yang Xie, Dong-Sheng Fang, Hong Jiang, Yun-Yang Lian

机构信息

a School of Pharmacy, Fujian Medical University , Fuzhou 350004 , P.R. China.

出版信息

Nat Prod Res. 2014;28(23):2134-9. doi: 10.1080/14786419.2014.926350. Epub 2014 Jun 18.

DOI:10.1080/14786419.2014.926350
PMID:24938666
Abstract

Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.

摘要

菌株FIM06054是从采集自中国东海的海洋海绵样本中分离得到的，根据其16S rRNA基因序列被鉴定为疣孢菌属的一个菌株。从疣孢菌属菌株FIM06054的培养液中分离出一种新化合物FW054-1（1）以及一种已知的氨基呋喃化合物proximicin A（2）。通过光谱分析阐明了它们的结构。1和2对几种人类肿瘤细胞系显示出抗增殖活性。

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