Cheng Daomei, Kong Haiyan, Pang Wei, Yang Hongpeng, Lu Hao, Huang Chengyu, Jiang Yugang
a Department of Nutrition , Tianjin Institute of Health and Environmental Medicine , Tianjin , China.
b Department of Nutrition and Food Safety , West China School of Public Health, Sichuan University , Chengdu , China.
Nutr Neurosci. 2016 Dec;19(10):461-466. doi: 10.1179/1476830514Y.0000000136. Epub 2016 Mar 2.
An intervention study was performed to determine if supplement containing folic acid, vitamin B, and vitamin B could improve cognitive function and lower homocysteine in middle-aged and elderly patients with hyperhomocysteinemia.
One hundred and four participants with hyperhomocysteinemia were recruited in Tianjin, China, aged 55-94 years old. Fifty-seven individuals with hyperhomocysteinemia were included in the intervention group (vitamin B group, which received 800 µg/day of folate, with 10 mg of vitamin B and 25 µg of vitamin B) and 47 patients in the placebo group. The endpoint was the improvement in cognitive function as evaluated by Basic Cognitive Aptitude Tests (BCATs). All parameters were measured before and after the treatment period of 14 weeks.
The BCAT total score and four sub-tests scores (digit copy, Chinese character rotation, digital working memory, and recognition of meaningless figure) of BCAT at 14 weeks significantly increased only for the vitamin B group. Serum total homocysteine (tHcy) levels significantly decreased in the intervention group, while serum concentrations of folate, vitamin B, and vitamin B significantly increased in the intervention group.
The results demonstrated that supplement containing folate, vitamin B, and vitamin B in middle-aged and elderly patients with hyperhomocysteinemia could improve their cognitive function partly and reduce serum tHcy levels.
进行一项干预研究，以确定含有叶酸、维生素B₆和维生素B₁₂的补充剂是否能改善高同型半胱氨酸血症中老年患者的认知功能并降低同型半胱氨酸水平。
在中国天津招募了104名年龄在55 - 94岁的高同型半胱氨酸血症参与者。干预组（维生素B组，每天服用800μg叶酸、10mg维生素B₆和25μg维生素B₁₂）纳入57名高同型半胱氨酸血症个体，安慰剂组纳入47名患者。终点是通过基本认知能力测试（BCATs）评估的认知功能改善情况。在14周的治疗期前后测量所有参数。
仅维生素B组在14周时BCAT总分及BCAT的四个子测试分数（数字抄写、汉字旋转、数字工作记忆和无意义图形识别）显著增加。干预组血清总同型半胱氨酸（tHcy）水平显著降低，而干预组血清叶酸、维生素B₆和维生素B₁₂浓度显著升高。
结果表明，含有叶酸、维生素B₆和维生素B₁₂的补充剂可部分改善高同型半胱氨酸血症中老年患者的认知功能并降低血清tHcy水平。
